CELL OF ORIGIN COMBINED WITH CNS INTERNATIONAL PROGNOSTIC INDEX IMPROVES IDENTIFICATION OF DLBCL PATIENTS WITH HIGH CNS RELAPSE RISK AFTER INITIAL IMMUNOCHEMOTHERAPY
نویسندگان
چکیده
منابع مشابه
CNS involvement in DLBCL.
A 70-year-old woman presented with 4 weeks of progressive bilateral lower extremity weakness. She had past medical history of stage III diffuse large B-cell lymphoma treated with 6 cycles of R-CHOP chemotherapy, which was completed 6 months prior to presentation. All risk factors for central nervous system (CNS) relapse were negative except for thickening of left paranasal sinus. A computed tom...
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Central nervous system (CNS) relapses are an uncommon yet devastating complication of non-Hodgkin lymphomas. The identification of patients at high risk of secondary CNS relapse is therefore paramount. Retrospective data indicate prophylactic CNS-directed therapies may reduce the risk of CNS involvement; however, no consensus exists about dose, timing, or route of therapy. In addition, prophyla...
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متن کاملRelapse pattern and prognostic factors for patients with primary CNS lymphoma
Age Median (Range) 59 (28-76) 53 (33-65) 0.260 Age 0.253 ≥60 20 (47.6%) 5 (27.8%) <60 22 (52.4%) 13 (72.2%) Gender 0.241 Male 25 (59.5%) 14 (77.8%) Female 17 (40.5%) 4 (22.2%) Involvement sites 1.000 Intracranial lesion only 38 (90.5%) 15 (83.3%) Extracranial involvement 6 3 Leptomeningeal seeding 4 2 Ocular lesion 1 1 Spinal cord 1 0 B Symptom 1.000 Yes 1 (2.4%) 0 (0.0%) No 41 (97.6%) 18 (100....
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ژورنال
عنوان ژورنال: Hematological Oncology
سال: 2017
ISSN: 0278-0232
DOI: 10.1002/hon.2437_25